So going from there, given that there will be 10-11 songs in Set 1, the mega-epic is probably the encore, especially if there are other "monster" tracks that could be mini-epics taking up a lot of time.
Hell's Kitchen is kind of a good guess, because it kills three birds with one stone (FII, instrumental, extended guitar solo). But TDOE, if it's still in the running for the opener, also does that.
Out of the mega-epics, it's probably not 6DOIT (definitely too long to fit in the first set, and too long for an encore). It's also probably not IT, due to "the" DT12 track being TBP/STR, and due to the fact that MM has not transcribed 2 "monster" tracks, one of which is probably this mega-epic. In other words, it's probably ACOS, 8VM or somewhat possibly ITPOE. I like to personally consider A Mind Beside Itself one epic track, because I think they all go together, but I think that's somewhat out of the mainstream of thought on that.
The only one of their instrumentals that can be ruled out really is EM.
A lot of songs could be a good place for extended guitar and drum solos, including basically all the instrumentals. ANB of course for the guitar solo, and that's pretty much assured to be on the setlist.
As for the albums:
BAI, OTBOA and Outcry are popular songs from ADTOE, probably in that order.
From FII, LOTS, ToT, and PS are either long enough to be "monster" tracks or have monster in the lyrics. MM would not have to transcribe ToT or PS, though. I don't think it's going to be any of the multiple ballads from this album, and it's probably not NM either, since James hates playing that one.
In fact, the easiest one to narrow down would be the non mega-epic monster track that MM does have to transcribe. We can rule out basically everything after SC, and of course it's not I&W or ACOS, and it's hard to see how anything on WDADU fits in. And then from there, it's probably not something he's already played. The only songs from Awake he hasn't played are IF, Erotomania, and Voices. It could be Voices. On FII, the only monsterish song MM hasn't played is LITS. He's played a lot of SFAM, but surprisingly, he hasn't yet played Home, which is sort of monsterish. TGP is also a really good guess here, and the only one that would really fit from 6DOIT. There's a few on ToT that would fit (TDS, SOC, ITNOG). SOC would also fill the instrumental category. Nothing on 8VM really fits. I think this can be narrowed down to about 7 songs: Voices, Home, LITS, TGP, TDS, SOC, or ITNOG. Interestingly, except for LITS, none of these other possibilities are on any of the albums we know from which there will be a song. So either the FII song is LITS -or- we can narrow down a fourth song to one of six choices.
Other than what I underlined above, it's kind of hard to glean anything else really specific about what else is in the setlist.