So... I suppose I have. I was a Project Manager/Division Manager for an environmental construction company and I wanted something different, so I went to GE as a Contract Manager in their Industrial Systems group (basically, home electronics, small electric motors, transformers, that kind of stuff).
I've never looked back.
I'm not in anything close to that now (I'm Senior Counsel in a company that builds trains) but everything I've done in the last 25 years has come from that jump. And that's sort of my advice; you can make a switch without abandoning everything. Don't look at your JOB, look at your SKILLSET and find an analogue. Obviously, if you have some industry connections, that important. There are some people who still believe "my industry is unique" and you'll fight that. But since that break, I was in industrial systems, I was back in environmental but as counsel for GE, I was in real estate, I was in liability transfer, I was in the passenger rail space, I was in the signaling business... find a company that has opportunity and will let you follow it.
This sounds complicated, but it's really not, if you're of the mindset and reframe yourself in the right way. I've not sold myself as a construction guy in 30 years, but I DO sell my project management skills, my negotiation skills and my transactional skills (particularly the last one). It gets easier, too; at this point I don't fight the "industry" problem; I can credibly say that I stepped into the consumer electronics industry, the heavy rail industry, the passenger rail industry and the signaling (software) industry without missing a beat.
I'm also enjoying myself more now than I have in 20 years.