Ok, after personal shit hiatus, I'm back!
Lordx, sorry to hear they passed you over, but it does sound like you interviewed well, and I hope you can take something from that. Way back in the day, I started this thread from experiences interviewing people who were terrible at interviews at relatively senior levels. So, even if this one didn't materialize, you should still fell confident about the next opportunity, you are well ahead of a lot of people.
And yeah, the internal candidate thing can suck. For us, we fulfill the letter of the requirement...if there is something where there is someone internal already picked, we post it for five days, then close it. That checks the box of posting it publicly but keeps the hassle to a minimum (and we also aren't leading anyone on). I've also seen what axeman describes...promotion and HR politics elude me sometimes.
My situation is about to get interesting. My employer is about to get gobbled up by one of the two big Chicago pharma companies (not Orbert's current one), the close is now expected in May. And, I've requested the severance package (culturally, the new company would be a terrible fit for me and there would be now growth opportunities). So now I'm networking, talking to recruiters, and preparing to interview, all virtually (and I'm going to have to start cutting y own hair, which will look GREAT on skype calls!). On top of this, it's the first time I will have (knowingly) interviewed in 15 years; then it was PhD entry level, now it's potentially VP level. So, I really have no idea what I'm doing here. Overall, I'm feeling ok about things, but I also now that reality hasn't quite set in yet.
One of the decisions that I'm facing is what the next role looks like. On one hand, there is a small company I've started talking to that would be a hand-in-glove fit with so much of my experience, to a point where I suspect I know some of their business better than they do; it sounds fun and exciting, and I would want to interview with them just to figure out how they are tackling certain regulatory and reimbursement challenges. On the other hand, I could try to catch on some place doing something where I have some recent experience but is still outside my comfort zone (gene therapy), and will offer a much better long-term trajectory for me. Unfortunately, I can't do the first then the second...going to the "comfortable" company would be a one-way valve, away from gene therapy (which is the wave of the future). I know the "hard" path is the right one...it's appealing to know that I could walk in some place and instantly be a rock star, but I'm guessing the shine would wear off in a year, and I'd wind up regretting it. Sigh...