I'm familiar with Pedro Pascal and Vanessa Kirby. Didn't recognize the name Ebon Moss-Bachrach, but it turns out I've seen him a few things. I thought Skeen was an interesting character, and Lieberman was pretty cool. Joseph Quinn is the only unknown for me. His list on IMDb is impressive; it's just all stuff I've never seen.
But as with anything else, what matters most is that it's well-written and well-acted. We haven't gotten that particular twofer for any Fantastic Four movie yet IMO. Third, or fourth, or fifth time's the charm?