Pretty much only animation aimed at children/family.
I feel Avatar The Way of Water shows it could be successful, if done well. Technically most mains have human roots, but aren't anymore on the screen. For most of it's near 3 hours runtime you are looking at cgi aliens and creatures with rarely a human on the screen. But no studio is going to risk hundreds of millions on such a big risk.
I do think the Transformers have a too big focus on the humans. But that is also because they are (to me) just written so badly and the films are a tonal mess.