I like where Marc is going with this. I would probably choose to do something similar, basing the movie off of mental illness.
However, I would aim to use only SDoIT as the soundtrack for it.
The movie would follow along with the idea of the song, taking us into the minds and lives of 6 different characters, all with a different mental illness. Though their illnesses are all different from each other, they would all share a common bond which would cause all of the characters to eventually meet each other.
From there, they'd each discover that their illnesses all have a counterpart which is actually a GIFT, and it would give them each a unique ability which ended up helping them throughout their lives, instead of hindering them.
For example, one of the 6 characters would be autistic, and would discover that he could pick up a guitar for the very first time and play anything. At this part of the movie, one of JP's solos from SDoIT could be playing, but it is actually the autistic guy playing the solo in the movie instead of JP.
Each character would go through a similar discovery in which they determine that their illness has given them a gift, and the movie could end with them all using their own illness against itself, and benefiting from it instead of living in pain from it.