I have actually listened to it once, but the transitions weren't the problem. It's that it drags too much, and the self-references are cool when you haven't heard the reference in a long time, but when the thing just happened 3 minutes earlier, it gets old.
Ahhh, if it's good enough for Awake and Scenes from a Memory! Self-references used to be DT's golf - Space-Dye Vest isn't far from the Mirror quote, and The Mirror reprise itself comes only about three minutes after the original song ended.
I think the only issue with playing it live would be the intensity - and even then, it's just The Glass Prison and This Dying Soul sitting back to back. It's currently structured a bit like...
1. Heavy
2. Heavy
3. Rock
4. Brooding
5. Heavy
Switch that to...
1. Heavy
2. Psychedelic
3. Rock
4. Brooding
5. Heavy
And it's a bit more diverse - but was never going to happen, not with Six Degrees and Train of Thought back to back! This Dying Soul's got a few psychedelic elements, that chorus is lush. Even now, though, I don't think it'd take much to sustain an audience's interest. If they can make their visual show as strong as it has been on this tour, if they can really tell a story musically and visually, I see no reason the Twelve Step Suite wouldn't be absolutely stellar in a live environment. Always used to sit on the side of, "That's... quite a long suite," but on the heels of this tour I think they could, and would want to, do it justice.