Our list is pretty extensive.
We donate to a homeless shelter here locally, as well as a soup kitchen, Childrens Hospital of Cincinnati, Cincinnati Zoo, Cincinnati Ballet, Cincinnati Museum Center, Cincinnati Symphony, and the Freestore Foodbank.
Nationally, and internationally we donate to:
Doctors Without Borders
Intrepid Fallen Heroes Fund
Easter Seals
American Red Cross
Marine Toys for Tots
Nature Conservancy
Wildlife Conservation Society
NWF
The Honeybee Conservancy
Amnesty International
Habitat for humanity
Ronald McDonald House
National Novel Writing Month -formerly Office of Letters and Light
Make A Wish
Bryce Harlow Foundation
First Book
Reading Is Fundamental
Susan B. Komen
Smithsonian Institute
International Elephant Fund
Save the Elepahnts
The Elephant Sanctuary
North American Indian Womens Assoc.
Cherokee Indian School Board
F & AM Ohio Masonic Home
Valley of Cincinnati Scottish Rite
We send checks for most. Do some work for others. All of these charities have had meaning for us in our personal lives somehow. It's great that you want to do something. I would choose a charity that you feel some sort of connection with and donate to that one. Then research it as much as you can. Not just from a monetary standpoint, but you can really find yourself getting involved in supporting the cause in other ways, which is very rewarding indeed. We get asked by a lot of other groups that we usually turn down. My wife likes to never say no, so even a small donation is usually forthcoming when anyone asks; but the charities I listed are ones we support each year for sure. And all of them need help in a big way.