First off, I mostly really like your set list, with the exception of Wither (which I don't know why anyone in their right mind would ever want to see played live). But if I were to critique it:
-Home is not a set opener. Great song. But not as an opener.
-If you are taking James struggling into account, Voices, Metropolis, and The Killing Hand are not great choices (great songs in and of themselves though).
-Nobody really wants a keyboard solo.
But that said, I again like the general direction. And I especially like Octavarium as the closer. I think Mike really liked playing it. And as I mentioned elsewhere awhile back, JP sounded pretty enthusiastic about doing it at some point when I mentioned it to him a little while back. Honestly, if they're going to find space in the set for a longer epic, and the next album doesn't have one, I think Octavarium might be a very likely choice. And I've been lobbying for ITNOG and Misunderstood to come back for a while now too.