Star Trek really needs to return to TV, with someone in charge who understands real scifi. TV is in desperate need of some scifi right now.
The question is where do you go with it? Another 75 years into the future? You've got two different gaps in what they've done, but you'd be so surrounded by canon that you'd be pretty limited. That's why VOY worked (at least to the two of us). You can't really set it in a static location, as we saw with DS9. The one thing JJA did right was finding a way to reboot the whole thing to provide a blank slate. Yet transferring that to TV wouldn't work without that cast, and sadly that won't happen.
That is a definite issue. Obviously they're not bringing this cast to TV, and recasting them would probably be lame and cheap, and recasting such iconic characters yet again for TV would be a real task. I don't think it's a wise idea to return to the prime universe at this point either, as much as I love it, for the reasons mentioned.
I think the most likely scenarios are either a new show that spins off shortly after the next movie, new characters/cast, that acknowledges the events of the movies, but isn't really connected to it, or they could reboot TNG in the new universe, make a few changes to reflect the new timeline, distance themselves from it while still having that blank slate.
I really don't know. I'm not saying these are the best options, but I see them as the most likely avenues for Trek to return to TV at this point.