It's funny, that's one game where I mostly am okay with a lot of the changes. I don't think Skyrim was as cut up and simplified in comparison to its predecessors as F4 was to the rest of its own series, but its definitely more streamlined, and in some instances dumbed down. But that goes with my own life changes and not having hours and hours to wander around exploring, which sucks. But I do think there's a definite balance to be had in that streamlined format of being able to explore and to have branching options of speech, factions, storyline trees and whatnot while still retaining the ease of access and "pick up/put down" play. I don't go back and play Morrowind/Oblivion as much as I do NV in comparison to Skyrim/4, respectively; but I can see how those changes would irk the lifelong fans just as much.
But yeah, at this point there's no going back. I'm just hoping that they do find some kind of balance as opposed to making it just more and more dumbed down. At least with 4 getting a whole lot of flack from fans new and old, there's precedent for change. Skyrim, maybe not so much, but there was still some good constructive criticism gained. I also don't think they'll be remaking and banking off of 4 nearly as much as they did with Skyrim. It'll be interesting what the next iteration for each of the series brings, that's for sure.