You can take the light rail from the airport to the NJ Transit Rail Station for the Airport (not sure if there is a charge for this) and then from the Airport train station you can hop on the train into Penn State NYC which is 3 stops away (maybe 20 minutes ride and will cost money). From Penn Station you can hop onto a subway, take a taxi, or just walk to 46th street (I typically would walk from 34th st to 46t, but maybe you'll have luggage).