Basically those are really advanced synthleads. The best way to start off is with a 'clean' synth lead. Mostly called a saw-lead, or something with 'saw' in it. You can start off with a square lead, but that's a lot less agressive to start with.
After that you can add some oscillators, make the sound sound thicker, or add some dirty chorus (not too much, you don't wanna sound too 80s) to do the same. And then the fun starts, overdrive, distortion, wah or autowah, phasers, flangers, stuff like that. Just experiment.
What kind of keys do you have, actually?