I've always been taught to share a genuine weakness, but turn it into a strength.
"I guess that I'm a little bit of a control freak. I do have a bit of a tendency to get agitated if I've done x amount of good work and then I come back and someone's moved everything around. So yeah, that's perhaps kind of inflexible, but once I take on a task I kind of need to see it through to completion myself and give it the full attention it deserves, so I'm not gonna change any time soon."
Resolute, accepts it as a flaw, but reflects well on you.