I hit two annoying bugs.
One, I got stuck on a piece of scenery and had to reload.
Two, during a firefight in the final mission, Shepard froze. I couldn't move or attack, but I could issue orders. My teammates killed the remaining guys so I saved, and reloaded and I was fine.
It's definitely not as bad as FO3, which I was playing right before I started ME2. I swear the game would crash pretty much every two hours or so. I've also had corrupt save games and numerous console freezes in FO3. Bethesda couldn't properly code a game to save their lives.