Yeah - really dig the Mass Relay idea! Though, I wouldn't honestly know where to begin with a sequel. Even with the explanations from the interview, it's too mad a universe, too far scorched for it to be a mantle I'd want to pick up. Writing the difference between destruction, control and synthesis, a universe that may or may not contain geth, quarians, synthetics - unenviable task. You'd need to pick up many, many years into the future. Let the ripples simmer down.
Wonder, though. I totally get why you're locked in as a human - there are enough choices as it is, and the narrative would morph beyond recognition if it were played from another species' perspective; but now that we've done Shepard's story... has anyone played Dragon Age? Where you can choose to be an elf, a dwarf, or a human? 'Cos I imagine a Mass Effect sequel would be set in an era where racial tension would've died down a little. Certainly humans wouldn't be the new kids on the block any more - especially not given that they've spent a third of the trilogy cementing the entire universe as their friends.
Which is a long-winded way of saying, given that BioWare now have precedent in that field, it'd be pretty plausible for a sequel to let you choose your species. Nothing too weird (or too potentially-extinct!) - I can't imagine they'd ever let you play SP as a geth or a drell or a volus - but I could totally imagine a game where you can choose between, say, asari biotics, salarian techs, turian soldiers or a human wildcard. Everyone would treat you slightly differently, but the basic story's the same.
But - irrelevant! I actually just came on here to announce that I'd unlocked the krogan vanguard. Please welcome to the fold - Urdnot Barry!
Is anyone still on multiplayer? Enjoying the new classes?